Project: Synaptic interactions between mesenchymal stromal cells and macrophages in auto-immune diseases and inflammatory condition
MSCs are characterized by the high plasticity and immunomodulating functions. In an inflammatory environment MSCs are expected to adapt themselves and respond to the physiologic or pathologic conditions. Residential macrophages are the first target cells of MSCs in tissue and their polarization are modulated according to the MSCs response. Reversely, polarized macrophages are also able to “prime” MSCs and help them to respond. The study is dedicated to discover the molecular communication of synaptic interaction between macrophage-MSC.