ENGINEER CNRS UMR5235 UNIVERSITÉ DE MONTPELLIER TEAM: LABORATOIRE LPHI "MISE EN PLACE DE L'IMMUNITÉ ET DE L'INFLAMMATION" TEL: +33 (0)4 67 14 92 04
EXPERTISE & methods:
Primary culture cells
Transgenesis
Cellular phenotyping, cell cycle by FACS analysis
Phagocytosis analysis
Inflammatory cytokines profiles analysis
Western blot signaling pathway
PCR/RT-PCR
Intravital cellular imaging on confocal (LSM) and spinning disk
Project: Establishment of immunity and inflammation
Transcriptomic profiling of macrophages population on zebrafish larvae Aim: Characterization of gene markers of macrophage polarization during caudal tail fin amputation
Animal and cellular models
Human, Mouse (stem cells), Zebrafish
Publications
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Groß, Felix Ellett,Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla and Mai Nguyen-Chi1. (2021). Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish.Front.Immunol.,26 March2021 https://doi.org/10.3389/fimmu.2021.636585
Jamal Tazi*, Christina Begon- Pescia, Noëlie Campos, Cécile Apolit, Aude Garcel & Didier Scherrer. (2021). Specific and selective induction of miR-124 in immune cells by the quinolone ABX464: A transformative therapy for inflammatory diseases. Drug Discovery Today, 2020 Dec 30; S1359-6446(20)30537-7.
Bayó-Puxan N, Terrasso AP, Creyssels S, Simão D, Begon-Pescia C, Lavigne M, Salinas S, et al., Kremer EJ.(2018). Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons. Sci Rep., 8(1):16644
Kota SK, Llères D, Bouschet T, Hirasawa R, Marchand A, Begon-Pescia C, Sanli I, Arnaud P, Journot L, Girardot M, Feil R. (2014). ICR non-coding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain. Dev Cell., pii: S1534-5807(14)00519-X