Agnès Coste
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Project: Macrophage polarization and nuclear receptors in inflammation, infection and tumor diseases.
Identification of signaling pathways and molecular mechanisms that control the M1/M2 polarization of macrophages during inflammatory, infectious and tumor diseases. Our team focused on LRH-1, PPARg, Nrf2 transcription factors and on bioactive lipids (prostaglandins, lipoxins…).
Development of pharmacological strategies to re-orient macrophage polarization toward a phenotype improving the outcome of the disease.
Identification of signaling pathways and molecular mechanisms that control the M1/M2 polarization of macrophages during inflammatory, infectious and tumor diseases. Our team focused on LRH-1, PPARg, Nrf2 transcription factors and on bioactive lipids (prostaglandins, lipoxins…).
Development of pharmacological strategies to re-orient macrophage polarization toward a phenotype improving the outcome of the disease.
Animal and Cellular models:
Human and murine peritoneal macrophages
Human and murine colonic macrophages
Murine bone marrow derived macrophages
SignR1 or SignR3 deficient mice.
STAT6, NRF2 or IL-13Rα deficient mice.
12/15-Lox or 5-Lox deficient mice.
Wound healing
Infections : fungal and parasitic
Tumor models : lymphoma and ovarian adenocarcinoma
- Cellular models :
Human and murine peritoneal macrophages
Human and murine colonic macrophages
Murine bone marrow derived macrophages
- Murine models :
SignR1 or SignR3 deficient mice.
STAT6, NRF2 or IL-13Rα deficient mice.
12/15-Lox or 5-Lox deficient mice.
- Experimental murine models :
Wound healing
Infections : fungal and parasitic
Tumor models : lymphoma and ovarian adenocarcinoma
Techniques and Methods:
Phenotypic characterization of macrophages (RT-PCR, flow cytometry, WB)
Functional characterization of macrophages (bioactive lipids, cytokines and chemokines, ROS, NO, microbicidal and tumoricidal activities)
Phenotypic characterization of macrophages (RT-PCR, flow cytometry, WB)
Functional characterization of macrophages (bioactive lipids, cytokines and chemokines, ROS, NO, microbicidal and tumoricidal activities)