Malaria, innate immunity and therapeutic implications
We are studying the role of innate immunity and particularly non opsnonic phagocytosis by macrophages of Plasmodium-infected red blood cells in malaria. Our interest is focused on severe malaria, and we work both on experimental models to study our hypothesis, and on samples from malaria patients to validate our concepts according to clinical data. We aim to propose new therapeutic strategies to treat more efficiently severe cases of malaria.
Animal and cellular models
C57BL/6 mice
Plasmodium falciparum culture
Peritoneal macrophages
PBMC and monocytes/macrophages from patients
Techniques and methods:
Experimental models of uncomplicated and severe malaria
Studies from whole blood and organs (spleen, brain)